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1. In a child with primary IGF deficiency of unknown etiology, how should treatment be started?

A. rhIGF-I (mecasermin) therapy at a dose of 150 µg per kilogram per dose given once daily. B. rhIGF-I (mecasermin) therapy at a dose of 80 µg per kilogram per dose given twice daily. C. rhIGF-I (mecasermin) therapy at a dose of 40 µg per kilogram per dose given twice daily in combination with growth hormone therapy at a dose of 50 µg per kilogram per day. D. Growth hormone therapy at a dose of 50 µg per kilogram per day.

2. What potential side effect of rhIGF-I (mecasermin) therapy is not seen in children receiving growth hormone therapy?

A. Hypoglycemia B. Lipohypertrophy C. Slipped capital femoral epiphysis D. intracranial hypertension

3. In a child with primary IGF deficiency due to a mutation of the growth hormone receptor (Laron Syndrome), what is the maintenance dose of rhIGF-I (mecasermin)?

A. rhIGF-I (mecasermin) therapy at a dose of 150 µg per kilogram per dose given twice daily. B. rhIGF-I (mecasermin) therapy at a dose of 80-120 µg per kilogram per dose given twice daily. C. rhIGF-I (mecasermin) therapy at a dose of 150 µg per kilogram per dose given once daily in combination with growth hormone therapy at a dose of 45 µg per kilogram per day. D. Growth hormone therapy at a dose of 100 µg per kilogram per day.

4. What drug is known to interact with rhIGF-I mecasermin therapy?

A. Methylphenidate B. Levothyroxine C. Testosterone D. Insulin

Evaluation Questions

5. To what extent did the program meet objective #1?

A. Excellent B. Very Good C. Good D. Fair E. Poor

6. To what extent did the program meet objective #2?

A. Excellent B. Very Good C. Good D. Fair E. Poor

7. Rate the effectiveness of how well the program related to your educational needs:

A. Excellent B. Very Good C. Good D. Fair E. Poor

8. Rate how well the active learning strategies (questions, cases, discussions) were appropriate and effective learning tools:

A. Excellent B. Very Good C. Good D. Fair E. Poor

9. Rate the quality of the faculty:

A. Excellent B. Very Good C. Good D. Fair E. Poor

10. Rate the effectiveness and the overall usefulness of the material presented:

A. Excellent B. Very Good C. Good D. Fair E. Poor

11. Rate the appropriateness of the examination for this activity:

A. Excellent B. Very Good C. Good D. Fair E. Poor

12. Rate the effectiveness of how well the activity related to your practice needs:

A. Excellent B. Very Good C. Good D. Fair E. Poor

13. Rate the effectiveness of how well the activity will help you improve patient care:

A. Excellent B. Very Good C. Good D. Fair E. Poor

14. Will the information presented cause you to change your practice?

A. Yes B. No

15. Are you committed to making these changes?

A. Yes B. No

16. As a result of this activity, did you learn something new?

A. Yes B. No

17. What is your practice setting or area of practice?

A. Community Pharmacy/Independent B. Community Pharmacy/Chain C. Hospital/Health Systems D. Administrative/Pharmacy Director E. Critical Care Pharmacy F. Long-term Care G. Managed Care/PBM H. Oncology I. Specialty Pharmacy J. Industry/Manufacturing

18. How many years have you been in practice?

A. <5 B. 5 – 10 C. 11 – 20 D. >20

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