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1. A patient mistook her weekly methotrexate prescription for daily. The label stated “once weekly,” however, she was not counseled in the pharmacy regarding weekly dosing. How would you categorize this event?

A. This was a preventable ADE. B. This was an unpreventable ADE. C. This was an ADR. D. None of the above.

2. Which of the following is an appropriate way to administer naloxone for reversal of opioid-related respiratory depression?

A. Intramuscular B. Intranasal C. Intravenous D. All of the above E. Unsure

3. A 62 yo female presents unresponsive to the emergency department 9 hours after her last dabigatran dose. CT imaging indicates an intracranial hemorrhage. Her hemoglobin is 10g/dL (baseline 11g/dL). What do you recommend for management of this patient's bleed?

A. A reversal agent is not indicated B. Administer vitamin K 10mg IV once C. Administer Idarucizumab 5g IV as two 2.5g infusions consecutively D. Administer Idarucizumab 5g IV as two 2.5g infusions 60 minutes apart E. Unsure

4. 4 hours later, the patient's CT brain indicates a new right-sided subdural hemorrhage. What do you recommend next for the management of this bleed?

A. The idarucizumab needs more time to take effect, do nothing B. Administer a dose of idarucizumab 2.5g IV every 4 hours until resolution of bleed C. Evidence for repeat dosing of idarucizumab is very limited, but may consider another dose of 5g IV as two 2.5g infusions consecutively D. Consider andexanet alfa high-dose infusion E. Unsure

5. In multiple states, which members of society are allowed access to naloxone to help address the current opioid epidemic?

A. Patients at risk of opioid overdose B. Family of patients at risk of opioid overdose C. Pre-hospital personnel (i.e. paramedics, law enforcement) D. All of the above E. Unsure

6. Which anticoagulant was not evaluated in the phase 3 trial that led to the FDA approval of andexanet alfa?

A. Apixaban B. Betrixaban C. Enoxaparin D. Rivaroxaban E. Unsure

7. Which of the following is true about digoxin-specific antibody fragments?

A. Are utilized to reverse the neurological symptoms of digoxin toxicity B. 40mg bind to about 0.5mg of digoxin C. Are only utilized for chronic, symptomatic digoxin toxicity D. Do not elevate total serum digoxin levels 24 hours after administration E. Unsure

8. Which of the following is true about co-administration of leucovorin and glucarpidase in the setting of methotrexate toxicity?

A. Leucovorin is not necessary during the administration of glucarpidase B. Leucovorin increases the efficacy of glucarpidase and should be administered at the same time C. Leucovorin competes with glucarpidase for the methotrexate-binding site D. Leucovorin should not be given within 2 hours of glucarpidase E. Unsure

9. In which patient scenario would administration of sugammadex be appropriate, and what dose would you recommend?

A. A patient was administered succinylcholine during rapid sequence intubation (RSI) but the provider discovered that her serum potassium was 6.2 mEq/L; sugammadex 1.2mg/kg B. Vecuronium 0.1mg/kg was given for RSI. After successful intubation, the provider wishes to reverse the neuromuscular blockade; sugammadex 2mg/kg C. Rocuronium 1mg/kg was administered during RSI. Four attempts were made to intubate the patient with failure due to difficult airway. The provider wishes to reverse the neuromuscular blockade and resume non-invasive ventilation; sugammadex 16mg/kg D. Vecuronium was administered during surgery. After a successful procedure, the patient's train-of-four is at 1 of 4; sugammadex 16mg/kg E. Unsure

10. Which healthcare safety organizations provides medical management advice in addition to injury surveillance through its national database.

A. Poison Control Centers B. Institute of Safe Medication Practices C. Food and Drug Administration D. Agency for Healthcare Research and Quality E. Unsure

Evaluation Questions

11. How confident are in your treatment choices for the 62 yo female in the previous questions:

A. Not at all confident B. Somewhat confident C. Confident D. Highly confident

Maintenance is scheduled for 8/7/2023 7:00 AM EST - 8:00 AM EST.

{{recommendationsA.Title}}

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1. A patient mistook her weekly methotrexate prescription for daily. The label stated “once weekly,” however, she was not counseled in the pharmacy regarding weekly dosing. How would you categorize this event?

2. Which of the following is an appropriate way to administer naloxone for reversal of opioid-related respiratory depression?

3. A 62 yo female presents unresponsive to the emergency department 9 hours after her last dabigatran dose. CT imaging indicates an intracranial hemorrhage. Her hemoglobin is 10g/dL (baseline 11g/dL). What do you recommend for management of this patient's bleed?

4. 4 hours later, the patient's CT brain indicates a new right-sided subdural hemorrhage. What do you recommend next for the management of this bleed?

5. In multiple states, which members of society are allowed access to naloxone to help address the current opioid epidemic?

6. Which anticoagulant was not evaluated in the phase 3 trial that led to the FDA approval of andexanet alfa?

7. Which of the following is true about digoxin-specific antibody fragments?

8. Which of the following is true about co-administration of leucovorin and glucarpidase in the setting of methotrexate toxicity?

9. In which patient scenario would administration of sugammadex be appropriate, and what dose would you recommend?

10. Which healthcare safety organizations provides medical management advice in addition to injury surveillance through its national database.

Evaluation Questions

11. How confident are in your treatment choices for the 62 yo female in the previous questions:

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Maintenance is scheduled for 8/7/2023 7:00 AM EST - 8:00 AM EST.

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1. A patient mistook her weekly methotrexate prescription for daily. The label stated “once weekly,” however, she was not counseled in the pharmacy regarding weekly dosing. How would you categorize this event?

2. Which of the following is an appropriate way to administer naloxone for reversal of opioid-related respiratory depression?

3. A 62 yo female presents unresponsive to the emergency department 9 hours after her last dabigatran dose. CT imaging indicates an intracranial hemorrhage. Her hemoglobin is 10g/dL (baseline 11g/dL). What do you recommend for management of this patient's bleed?

4. 4 hours later, the patient's CT brain indicates a new right-sided subdural hemorrhage. What do you recommend next for the management of this bleed?

5. In multiple states, which members of society are allowed access to naloxone to help address the current opioid epidemic?

6. Which anticoagulant was not evaluated in the phase 3 trial that led to the FDA approval of andexanet alfa?

7. Which of the following is true about digoxin-specific antibody fragments?

8. Which of the following is true about co-administration of leucovorin and glucarpidase in the setting of methotrexate toxicity?

9. In which patient scenario would administration of sugammadex be appropriate, and what dose would you recommend?

10. Which healthcare safety organizations provides medical management advice in addition to injury surveillance through its national database.

Evaluation Questions

11. How confident are in your treatment choices for the 62 yo female in the previous questions:

« Return to Activity

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