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1. What proportion of smokers are successful in sustaining a long-term quit attempt with no outside support or intervention?

A. About 50% B. About 33% C. About 10% D. Less than 5%

2. Studies comparing the efficacy of pharmacologic smoking cessation methods showed:

A. Varenicline and buproprion had equivalent efficacy and were superior to nicotine replacement therapies B. Varenicline had the highest efficacy as a monotherapy and was generally equivalent to combination nicotine replacement methods (e.g., patch plus gum) C. Nicotine replacement products worked better than oral pharmacotherapies but cannot be used for a sustained period of time D. All methods had equivalent efficacy to each other but were better than placebo

3. The current guidance regarding the neuropsychiatric safety of varenicline is:

A. Varenicline label contains a black box warning about the risk of serious neuropsychiatric symptoms B. The EAGLES study showed no increased risk of psychiatric problems among patients using varenicline C. The FDA and European Medicines Agency allowed removal of the black box warning based on EAGLES and other postmarketing data D. Both B and C above

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