1. Which of the following biomarkers is currently incorporated into product label indications for anti-PD-1/PD-L1 drug use in specific designated tumor types?

2. Which of the following biomarkers is associated with an agnostic indication for anti-PD-1/PD-L1 immunotherapies?

3. Which of the following laboratory test methodologies can be used to determine both tumor programmed death-ligand 1 (PD-L1) expression and tumor mutation burden (TMB)?

4. A patient with an excellent performance status and diagnosed with metastatic non-small cell lung cancer undergoes a tissue biopsy. Laboratory testing reveals: absence of EGFR activating mutations, negative ALK gene rearrangement/fusions, wild-type ROS1 and BRAF, and programmed death-ligand 1 (PD-L1) positivity >50%. Which of the following initial treatments is most appropriate?

5. Prior to 2018, the Centers for Medicare and Medicaid “14 Day Rule” had which of the following impacts on independent labs when billing for services?

6. According to Dr. Oxnard, what patient information should be gathered to inform treatment decisions for patients with non-small cell lung cancer in which immuno-oncology therapy may be a treatment option?

Evaluation Questions

7. How confident are you in your decision about treatment for the patient in the question above?

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