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1. Which of the following enzymes in the B-cell receptor (BCR) pathway are targeted by agents that are currently FDA approved?

A. BTK B. SYK C. PI3K D. Both BTK and PI3K

2. Which of the following have been proposed as potential BTK resistance mitigation strategies?

A. Switching to second generation BTK inhibitors (i.e., acalabrutinib) B. Developing reversible, non-covalent BTK inhibitors C. Employing ibrutinib or acalabrutinib as combination therapy D. Using ibrutinib at higher doses

3. Lymphocytosis with BTK inhibitor initiation is:

A. Expected in most patients with B-cell malignancies and will resolve over the course of several weeks B. A sign of rapid disease progression C. Preventable with concomitant antihistamine use D. An indication of medication intolerance

4. ML is a newly-diagnosed CLL patient taking ibrutinib. When is it clinically appropriate to switch ML to acalabrutinib?

A. After detection of PLCG2 mutation B. After the patient has acquired resistance to ibrutinib C. When the patient is intolerant to ibrutinib D. After detection of Cys481s mutation

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