1. Which term describes the phenomenon of patients experiencing a vascular event after being aggressively treated for cardiovascular disease risk factor reduction with current evidence-based recommendations?

2. Which of the following diabetes medications have reported reductions in cardiovascular disease outcomes from cardiovascular outcome trials in type 2 diabetes mellitus?

3. What effect do dipeptidyl peptidase-4 inhibitors have on the risks of death, myocardial infarction, and stroke according to cardiovascular outcome trials conducted to date?

4. Empagliflozin decreased which of the following outcomes?

5. Real world, retrospective data demonstrated that death and heart failure were reduced with the use of sodium-glucose cotransporter-2 (SGLT-2) inhibitors. Which SGLT-2 inhibitors were most common among participants?

6. Which of the following outcomes dictates that pioglitazone will likely not be used for first-line prevention of cardiovascular disease?

7. A patient has had a myocardial infarction. Which glucagon-like peptide-1 receptor agonist has been shown to decrease the risk of a recurrent MI?

8. A patient with type 2 diabetes mellitus is committed to lifestyle changes to manage his disease, and he currently takes a sulfonylurea and metformin at maximum tolerated doses. His hemoglobin A1c level is 9%. He also takes a statin and 2 blood pressure medications, including lisinopril 80 mg daily; he has microalbuminuria and an estimated glomerular filtration rate of 78 ml/min/1.73 m2. Which medication could be added to this patient's regimen to help with glycemic control and slow progression of renal disease?

9. The Trial Comparing Cardiovascular Safety of Insulin Degludec Versus Insulin Glargine in Subjects with Type 2 Diabetes at High Risk of Cardiovascular Events (DEVOTE) reported what cardiovascular results with long-acting insulins?

10. The mechanisms for cardiovascular disease improvement with sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists are likely the same.

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