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1. Which of the following findings is supportive of the diagnosis of multifocal motor neuropathy (MMN):

A. Absence of conduction block (CB) on nerve conduction studies B. Elevated protein concentration in cerebral spinal fluid C. Elevated titers of serum IgM D. Positive therapeutic response to corticosteroid therapy

2. Which of the following is a characteristic finding in patients with MMN:

A. Impaired muscle grip strength in both left and right hands B. Intolerable neuropathic pain in the lower extremities C. Persistent fatigue D. Progressive respiratory decline

3. MMN differs from amyotrophic lateral sclerosis (ALS) by the presence of which of the following:

A. Upper motor neuron signs B. Bulbar findings C. Predominant sensory findings D. Asymmetrical weakness with wrist extension

4. Which of the following is recommended first-line treatment for MMN:

A. Therapeutic plasma exchange B. Prednisone orally once daily C. Methylprednisolone intravenously once daily D. Intravenous immune globulin (IVIg)

5. CK is an otherwise healthy man, 40 years of age, (weight 165 lbs [75 kilograms]) recently diagnosed with MMN. Which of the following is an appropriate treatment regimen for IVIg induction therapy:

A. 2 g/kg given over 5 days B. 1 g/kg given over 5 days C. 0.5 g/kg given over 5 days D. 0.4 g/kg given over 5 days

6. ZG is a man, 53 year years of age, with MMN with progressive disease who has failed to respond to 3 separate courses of IVIg therapy. Which of the following would be an appropriate treatment alternative for ZG:

A. Therapeutic plasma exchange B. Corticosteroids C. Cyclophosphamide D. Subcutaneous immunoglobulin (SCIg)

7. Which of the following is an appropriate maintenance therapy for a patient with MMN:

A. Intravenous immunoglobulin 1 g/kg dosed once monthly B. SCIg 1 g/kg dosed once daily C. Prednisone 60 mg orally once daily D. Therapeutic plasma exchange once monthly

8. For patients undergoing induction therapy with immune globulin for MMN, which of the following parameters should be closely monitored as part of a treatment plan:

A. Kidney function B. Liver function test C. Serum concentration of IgM D. B lymphocyte count

9. Which of the following medications work by inhibiting complement factor 5 and preventing formation of the membrane attack complex (MAC):

A. Eculizumab B. Interferon beta-1a C. Rituximab D. Infliximab

10. Based upon available clinical evidence, which of the following biological therapies may be beneficial for the treatment of patients with MMN:

A. Rituximab B. Fingolimod C. Natalizumab D. Infliximab

Evaluation Questions

11. To what extent did the program meet objective #1?

A. Excellent B. Very Good C. Good D. Fair E. Poor

12. To what extent did the program meet objective #2?

A. Excellent B. Very Good C. Good D. Fair E. Poor

13. To what extent did the program meet objective #3?

A. Excellent B. Very Good C. Good D. Fair E. Poor

14. To what extent did the program meet objective #4?

A. Excellent B. Very Good C. Good D. Fair E. Poor

15. To what extent did the program meet objective #5?

A. Excellent B. Very Good C. Good D. Fair E. Poor

16. Rate the effectiveness of how well the program related to your educational needs:

A. Excellent B. Very Good C. Good D. Fair E. Poor

17. Rate how well the active learning strategies (questions, cases, discussions) were appropriate and effective learning tools:

A. Excellent B. Very Good C. Good D. Fair E. Poor

18. Rate the quality of the faculty:

A. Excellent B. Very Good C. Good D. Fair E. Poor

19. Rate the effectiveness and the overall usefulness of the material presented:

A. Excellent B. Very Good C. Good D. Fair E. Poor

20. Rate the appropriateness of the examination for this activity:

A. Excellent B. Very Good C. Good D. Fair E. Poor

21. Rate the effectiveness of how well the activity related to your practice needs:

A. Excellent B. Very Good C. Good D. Fair E. Poor

22. Rate the effectiveness of how well the activity will help you improve patient care:

A. Excellent B. Very Good C. Good D. Fair E. Poor

23. Will the information presented cause you to change your practice?

A. Yes B. No

24. Are you committed to making these changes?

A. Yes B. No

25. As a result of this activity, did you learn something new?

A. Yes B. No

26. What is your practice setting or area of practice?

A. Community Pharmacy/Independent B. Community Pharmacy/Chain C. Hospital/Health Systems D. Administrative/Pharmacy Director E. Critical Care Pharmacy F. Long-term Care G. Managed Care/PBM H. Oncology/Specialty Pharmacy I. Industry/Manufacturing

27. How many years have you been in practice?

A. <5 B. 5 – 10 C. 11 – 20 D. >20

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